TRAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901856Biological processnegative regulation of cellular respiration
GO_0061077Biological processchaperone-mediated protein folding
GO_1903427Biological processnegative regulation of reactive oxygen species biosynthetic process
GO_0009386Biological processtranslational attenuation
GO_1903751Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO_0006457Biological processprotein folding
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005654Cellular componentnucleoplasm
GO_0005743Cellular componentmitochondrial inner membrane
GO_0071944Cellular componentcell periphery
GO_0005759Cellular componentmitochondrial matrix
GO_0019901Molecular functionprotein kinase binding
GO_0051082Molecular functionunfolded protein binding
GO_0140662Molecular functionATP-dependent protein folding chaperone
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameTRAP1
Protein nameTNF receptor associated protein 1
Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)
TNF receptor associated protein 1 (TNF receptor-associated protein 1, isoform CRA_b)
TNF receptor-associated protein 1
TRAP1 protein
TNF receptor-associated protein 1 (cDNA FLJ33058 fis, clone TRACH1000181, highly similar to Heat shock protein 75 kDa, mitochondrial)
SynonymshCG_16634
HSP75
DescriptionFUNCTION: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. .

AccessionsI3L2D5
ENST00000575707.5
I3L239
I3L253
I3L3L4
I3L0P6
Q5CAQ4
Q12931
ENST00000574175.1
ENST00000571538.5
Q9BV61
I3L4L7
ENST00000538171.5 [Q12931-2]
ENST00000246957.10 [Q12931-1]
ENST00000570403.1
ENST00000575671.5
I3L0K7
K0A7K7
ENST00000571804.5
ENST00000576335.5
ENST00000571011.1