TRABD2B | OmnibusX

Name	Number of supported studies	Average coverage
smooth muscle cell	4 studies	24% ± 8%	Explore
hepatocyte	3 studies	30% ± 10%	Explore

Name	Number of supported studies	Average coverage
kidney	3 studies	34% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	4659.16	89 / 89	94%	33.58	848 / 901
pancreas	92%	492.39	303 / 328	75%	4.45	134 / 178
liver	90%	680.77	203 / 226	45%	3.00	181 / 406
breast	97%	967.80	446 / 459	37%	2.07	414 / 1118
prostate	100%	1246.31	245 / 245	30%	0.92	151 / 502
bladder	100%	1315.52	21 / 21	14%	0.73	70 / 504
esophagus	89%	959.97	1289 / 1445	21%	1.05	39 / 183
lung	94%	569.20	544 / 578	16%	0.64	189 / 1155
intestine	89%	705.38	863 / 966	14%	0.63	72 / 527
blood vessel	100%	4865.32	1335 / 1335	0%	0	0 / 0
adipose	95%	770.93	1148 / 1204	0%	0	0 / 0
uterus	76%	431.86	129 / 170	18%	1.08	84 / 459
thymus	73%	320.52	475 / 653	15%	1.00	88 / 605
adrenal gland	63%	243.90	163 / 258	23%	1.84	53 / 230
stomach	58%	399.91	208 / 359	26%	1.34	74 / 286
skin	68%	344.91	1227 / 1809	7%	0.48	32 / 472
spleen	74%	385.07	179 / 241	0%	0	0 / 0
heart	72%	923.20	616 / 861	0%	0	0 / 0
ovary	31%	190.33	55 / 180	9%	0.50	39 / 430
muscle	14%	50.05	115 / 803	0%	0	0 / 0
brain	10%	41.16	271 / 2642	2%	0.07	12 / 705
tonsil	0%	0	0 / 0	4%	0.15	2 / 45
eye	0%	0	0 / 0	3%	0.06	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0030178	Biological process	negative regulation of Wnt signaling pathway
GO_0016055	Biological process	Wnt signaling pathway
GO_1904808	Biological process	positive regulation of protein oxidation
GO_0006508	Biological process	proteolysis
GO_0031334	Biological process	positive regulation of protein-containing complex assembly
GO_0031090	Cellular component	organelle membrane
GO_0005886	Cellular component	plasma membrane
GO_0017147	Molecular function	Wnt-protein binding
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

Gene name	TRABD2B
Protein name	Metalloprotease TIKI2 (EC 3.4.-.-) (Heart, kidney and adipose-enriched transmembrane protein homolog) (TRAB domain-containing protein 2B)
Synonyms	TIKI2 HKAT
Description	FUNCTION: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. .
Accessions	ENST00000606738.3 A6NFA1

TRABD2B report