TPRKB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	17 studies	27% ± 11%	Explore
B cell	7 studies	19% ± 7%	Explore
conventional dendritic cell	6 studies	29% ± 14%	Explore
epithelial cell	6 studies	42% ± 21%	Explore
endothelial cell of vascular tree	6 studies	23% ± 3%	Explore
CD4-positive, alpha-beta T cell	5 studies	19% ± 4%	Explore
erythroblast	5 studies	31% ± 16%	Explore
hematopoietic precursor cell	4 studies	34% ± 14%	Explore
plasmablast	4 studies	42% ± 16%	Explore
non-classical monocyte	4 studies	24% ± 6%	Explore
capillary endothelial cell	4 studies	24% ± 4%	Explore
glomerular endothelial cell	4 studies	38% ± 8%	Explore
progenitor cell	4 studies	17% ± 1%	Explore
pericyte	4 studies	19% ± 5%	Explore
fibroblast	4 studies	24% ± 9%	Explore
ciliated cell	4 studies	32% ± 9%	Explore
natural killer cell	4 studies	23% ± 7%	Explore
basal cell	4 studies	31% ± 14%	Explore
secretory cell	4 studies	29% ± 9%	Explore
plasmacytoid dendritic cell	4 studies	24% ± 5%	Explore
hematopoietic stem cell	4 studies	20% ± 3%	Explore
classical monocyte	3 studies	23% ± 7%	Explore
endothelial cell of artery	3 studies	19% ± 2%	Explore
neural crest cell	3 studies	23% ± 4%	Explore
vein endothelial cell	3 studies	25% ± 6%	Explore
precursor B cell	3 studies	29% ± 12%	Explore
neuron	3 studies	29% ± 14%	Explore
macrophage	3 studies	27% ± 8%	Explore
CD8-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
dendritic cell	3 studies	39% ± 10%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	39% ± 21%	Explore
enteroendocrine cell	3 studies	26% ± 9%	Explore
transit amplifying cell	3 studies	21% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	5 studies	25% ± 7%	Explore
peripheral blood	4 studies	23% ± 7%	Explore
intestine	3 studies	24% ± 10%	Explore
liver	3 studies	32% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	900.57	21 / 21	100%	38.00	504 / 504
breast	100%	983.69	459 / 459	100%	39.92	1118 / 1118
esophagus	100%	843.64	1445 / 1445	100%	32.92	183 / 183
ovary	100%	1233.89	180 / 180	100%	41.13	430 / 430
prostate	100%	976.21	245 / 245	100%	32.98	502 / 502
stomach	100%	707.80	359 / 359	100%	32.74	286 / 286
uterus	100%	1058.24	170 / 170	100%	48.37	459 / 459
thymus	100%	660.21	653 / 653	100%	26.81	604 / 605
brain	100%	690.73	2637 / 2642	100%	34.22	705 / 705
liver	100%	479.41	226 / 226	100%	22.63	405 / 406
pancreas	100%	570.92	327 / 328	100%	25.06	178 / 178
adrenal gland	100%	754.47	258 / 258	100%	21.98	229 / 230
intestine	100%	830.47	966 / 966	99%	32.56	524 / 527
lung	99%	633.66	574 / 578	100%	32.98	1155 / 1155
kidney	100%	925.79	89 / 89	98%	27.18	887 / 901
skin	100%	785.00	1808 / 1809	97%	25.08	457 / 472
adipose	100%	840.12	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	35.65	29 / 29
muscle	100%	1180.33	803 / 803	0%	0	0 / 0
spleen	100%	922.28	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	37.85	45 / 45
ureter	0%	0	0 / 0	100%	16.66	1 / 1
blood vessel	100%	748.49	1334 / 1335	0%	0	0 / 0
heart	99%	746.77	850 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	16.81	76 / 80
peripheral blood	53%	350.75	488 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002949	Biological process	tRNA threonylcarbamoyladenosine modification
GO_0000408	Cellular component	EKC/KEOPS complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0019901	Molecular function	protein kinase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TPRKB
Protein name	EKC/KEOPS complex subunit TPRKB (PRPK-binding protein) (TP53RK-binding protein)
Synonyms	CGI-121 My019
Description	FUNCTION: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine . The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 . TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification . .
Accessions	ENST00000318190.7 [Q9Y3C4-3] ENST00000707640.1 [Q9Y3C4-3] Q9Y3C4 ENST00000707638.1 [Q9Y3C4-1] ENST00000409716.6 [Q9Y3C4-3] ENST00000272424.11 [Q9Y3C4-1] ENST00000707641.1 [Q9Y3C4-3]

TPRKB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review