TOP1MT report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TOP1MT at tissue level.

III. Associated gene sets

GO_0006260Biological processDNA replication
GO_0006265Biological processDNA topological change
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0042645Cellular componentmitochondrial nucleoid
GO_0005739Cellular componentmitochondrion
GO_0003677Molecular functionDNA binding
GO_0003917Molecular functionDNA topoisomerase type I (single strand cut, ATP-independent) activity

IV. Literature review

[source]
Gene nameTOP1MT
Protein nameDNA topoisomerase (EC 5.6.2.1)
DNA topoisomerase I (EC 5.6.2.1) (DNA topoisomerase 1)
DNA topoisomerase I mitochondrial
DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1)
TOP1MT protein
Synonyms
DescriptionFUNCTION: Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). .

FUNCTION: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. .

AccessionsENST00000521193.5 [Q969P6-2]
E5RFS0
E5RJ33
ENST00000522043.1
E5RGR4
ENST00000518007.5
ENST00000523417.5
E5RIC7
E5RGE7
H0YC03
ENST00000518760.5
ENST00000519148.5 [Q969P6-2]
Q8TBP3
H0YBR3
E5RFE3
ENST00000518951.6
ENST00000522121.5
ENST00000520950.5
ENST00000519977.5
H0YAR3
E5RJ95
ENST00000329245.9 [Q969P6-1]
ENST00000522041.5
ENST00000519139.6
E5RGR2
ENST00000523676.5 [Q969P6-2]
Q969P6
ENST00000519591.5