TOMM70 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032728Biological processpositive regulation of interferon-beta production
GO_0030150Biological processprotein import into mitochondrial matrix
GO_0061052Biological processnegative regulation of cell growth involved in cardiac muscle cell development
GO_0098586Biological processcellular response to virus
GO_0042981Biological processregulation of apoptotic process
GO_0045040Biological processprotein insertion into mitochondrial outer membrane
GO_0002218Biological processactivation of innate immune response
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0006626Biological processprotein targeting to mitochondrion
GO_0097068Biological processresponse to thyroxine
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0045039Biological processprotein insertion into mitochondrial inner membrane
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0140596Cellular componentTOM complex
GO_0070062Cellular componentextracellular exosome
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005742Cellular componentmitochondrial outer membrane translocase complex
GO_0060090Molecular functionmolecular adaptor activity
GO_0008320Molecular functionprotein transmembrane transporter activity
GO_0030943Molecular functionmitochondrion targeting sequence binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTOMM70
Protein nameMitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70)
SynonymsKIAA0719
TOMM70A
TOM70
DescriptionFUNCTION: Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) . Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner . Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection . Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis . .

AccessionsENST00000284320.6
O94826