I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| cardiac muscle cell | 7 studies | 69% ± 15% | |
| fibroblast | 3 studies | 27% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| cardiac muscle cell | 7 studies | 69% ± 15% | |
| fibroblast | 3 studies | 27% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| heart | 7 studies | 28% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 36% | 51.47 | 64 / 180 | 86% | 4.33 | 370 / 430 |
| lung | 82% | 261.48 | 476 / 578 | 37% | 1.61 | 428 / 1155 |
| heart | 100% | 153957.77 | 861 / 861 | 0% | 0 | 0 / 0 |
| muscle | 98% | 221.99 | 786 / 803 | 0% | 0 | 0 / 0 |
| skin | 71% | 69.66 | 1287 / 1809 | 14% | 0.35 | 65 / 472 |
| adrenal gland | 58% | 110.43 | 149 / 258 | 17% | 1.07 | 40 / 230 |
| uterus | 27% | 28.75 | 46 / 170 | 44% | 3.14 | 204 / 459 |
| intestine | 29% | 17.57 | 276 / 966 | 38% | 1.32 | 199 / 527 |
| brain | 59% | 57.79 | 1553 / 2642 | 5% | 0.11 | 37 / 705 |
| stomach | 25% | 15.26 | 90 / 359 | 36% | 1.03 | 103 / 286 |
| thymus | 56% | 46.18 | 366 / 653 | 5% | 0.20 | 28 / 605 |
| esophagus | 39% | 27.65 | 563 / 1445 | 21% | 0.51 | 38 / 183 |
| breast | 31% | 110.37 | 142 / 459 | 26% | 1.16 | 291 / 1118 |
| kidney | 38% | 24.22 | 34 / 89 | 18% | 0.94 | 160 / 901 |
| pancreas | 26% | 21.93 | 84 / 328 | 24% | 0.71 | 43 / 178 |
| bladder | 5% | 2.48 | 1 / 21 | 29% | 1.25 | 148 / 504 |
| adipose | 33% | 39.39 | 395 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 29% | 97.12 | 71 / 245 | 3% | 0.07 | 13 / 502 |
| peripheral blood | 31% | 24.59 | 284 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 30% | 652.81 | 407 / 1335 | 0% | 0 | 0 / 0 |
| liver | 18% | 13.60 | 41 / 226 | 11% | 0.41 | 44 / 406 |
| spleen | 17% | 9.98 | 42 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 16% | 0.58 | 7 / 45 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.09 | 4 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010882 | Biological process | regulation of cardiac muscle contraction by calcium ion signaling |
| GO_0003009 | Biological process | skeletal muscle contraction |
| GO_0007507 | Biological process | heart development |
| GO_0001980 | Biological process | regulation of systemic arterial blood pressure by ischemic conditions |
| GO_0006940 | Biological process | regulation of smooth muscle contraction |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0032780 | Biological process | negative regulation of ATP-dependent activity |
| GO_0060048 | Biological process | cardiac muscle contraction |
| GO_0055010 | Biological process | ventricular cardiac muscle tissue morphogenesis |
| GO_0060047 | Biological process | heart contraction |
| GO_1990584 | Cellular component | cardiac Troponin complex |
| GO_0097512 | Cellular component | cardiac myofibril |
| GO_0005861 | Cellular component | troponin complex |
| GO_0030017 | Cellular component | sarcomere |
| GO_0005829 | Cellular component | cytosol |
| GO_0019904 | Molecular function | protein domain specific binding |
| GO_0030172 | Molecular function | troponin C binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0048306 | Molecular function | calcium-dependent protein binding |
| GO_0019855 | Molecular function | calcium channel inhibitor activity |
| GO_0031014 | Molecular function | troponin T binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003779 | Molecular function | actin binding |
| Gene name | TNNI3 |
| Protein name | Troponin I type 3 Troponin I3, cardiac type Cardiac troponin I Troponin I, cardiac muscle (Cardiac troponin I) Cardiac troponin I (Troponin I type 3 cardiac) Troponin I, cardiac muscle |
| Synonyms | TNNC1 |
| Description | FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. . FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. . FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. . FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. . FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. . FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. . |
| Accessions | ENST00000665070.1 ENST00000588882.1 A9UD06 B6D427 A8CLQ8 K7EN02 A0A590UJN1 K7EJP0 A8CN18 P19429 Q2PT48 A0A1B1HY27 Q6FGX2 ENST00000344887.10 A8CLR6 ENST00000586858.1 A8CLS6 Q6FGU5 |
