TNFAIP8L2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TNFAIP8L2 at tissue level.

III. Associated gene sets

GO_0050868Biological processnegative regulation of T cell activation
GO_0050728Biological processnegative regulation of inflammatory response
GO_0042981Biological processregulation of apoptotic process
GO_0042110Biological processT cell activation
GO_0045087Biological processinnate immune response
GO_0005764Cellular componentlysosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNFAIP8L2
Protein nameTumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2) (Inflammation factor protein 20)
Synonyms
DescriptionFUNCTION: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis . Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression . Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex . Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity). .

AccessionsQ6P589
ENST00000368910.4