TMTC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035269Biological processprotein O-linked mannosylation
GO_0006396Biological processRNA processing
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0004169Molecular functiondolichyl-phosphate-mannose-protein mannosyltransferase activity
GO_0000030Molecular functionmannosyltransferase activity

IV. Literature review

[source]
Gene nameTMTC1
Protein nameProtein O-mannosyl-transferase TMTC1 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 1) (Transmembrane and tetratricopeptide repeat-containing 1)
Transmembrane O-mannosyltransferase targeting cadherins 1
dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109)
SynonymsARG99
DescriptionFUNCTION: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. .

AccessionsENST00000550354.1
ENST00000539277.6 [Q8IUR5-5]
F8VXU8
Q8IUR5
ENST00000256062.9 [Q8IUR5-1]
F8VTQ9
ENST00000552618.5
H0YIB9
ENST00000551659.6