TMOD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008344Biological processadult locomotory behavior
GO_0007015Biological processactin filament organization
GO_0051694Biological processpointed-end actin filament capping
GO_0006936Biological processmuscle contraction
GO_0070307Biological processlens fiber cell development
GO_0030239Biological processmyofibril assembly
GO_0030863Cellular componentcortical cytoskeleton
GO_0030016Cellular componentmyofibril
GO_0008180Cellular componentCOP9 signalosome
GO_0030017Cellular componentsarcomere
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0005865Cellular componentstriated muscle thin filament
GO_0016020Cellular componentmembrane
GO_0005884Cellular componentactin filament
GO_0005523Molecular functiontropomyosin binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameTMOD1
Protein nameTropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
SynonymsD9S57E
TMOD
DescriptionFUNCTION: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. .

AccessionsP28289
ENST00000395211.6 [P28289-1]
ENST00000259365.9 [P28289-1]
ENST00000375175.1 [P28289-2]