TMEM43 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006629Biological processlipid metabolic process
GO_0071763Biological processnuclear membrane organization
GO_0045087Biological processinnate immune response
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0005637Cellular componentnuclear inner membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTMEM43
Protein nameTransmembrane protein 43 isoform 2
Transmembrane protein 43
Transmembrane protein 43 (Protein LUMA)
Transmembrane protein 43 isoform 1 (Transmembrane protein 43, isoform CRA_a)
SynonymsUNQ2564/PRO6244
hCG_27238
DescriptionFUNCTION: May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 . In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 . Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination . .

AccessionsA0A024R2F9
Q9BTV4
A0A0S2Z5N2
F8WDL3
ENST00000306077.5
ENST00000432444.2