Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 11 studies | 25% ± 9% | |
type II pneumocyte | 10 studies | 34% ± 11% | |
oligodendrocyte | 10 studies | 24% ± 7% | |
type I pneumocyte | 9 studies | 29% ± 8% | |
endothelial cell | 8 studies | 25% ± 9% | |
epithelial cell | 8 studies | 34% ± 19% | |
GABAergic neuron | 7 studies | 37% ± 20% | |
oligodendrocyte precursor cell | 6 studies | 28% ± 8% | |
glutamatergic neuron | 5 studies | 49% ± 23% | |
goblet cell | 5 studies | 26% ± 14% | |
club cell | 5 studies | 26% ± 9% | |
neuron | 4 studies | 28% ± 8% | |
adipocyte | 4 studies | 18% ± 2% | |
ciliated cell | 4 studies | 30% ± 7% | |
fibroblast | 4 studies | 21% ± 5% | |
interneuron | 4 studies | 40% ± 21% | |
B cell | 3 studies | 18% ± 1% | |
GABAergic interneuron | 3 studies | 15% ± 0% | |
abnormal cell | 3 studies | 29% ± 11% | |
myofibroblast cell | 3 studies | 19% ± 4% | |
macrophage | 3 studies | 21% ± 3% | |
basal cell | 3 studies | 39% ± 12% | |
transit amplifying cell | 3 studies | 32% ± 20% | |
plasmacytoid dendritic cell | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1752.21 | 459 / 459 | 100% | 35.99 | 1118 / 1118 |
esophagus | 100% | 1781.24 | 1445 / 1445 | 100% | 32.72 | 183 / 183 |
liver | 100% | 2812.81 | 226 / 226 | 100% | 30.94 | 406 / 406 |
lung | 100% | 3666.43 | 578 / 578 | 100% | 41.20 | 1155 / 1155 |
prostate | 100% | 2198.81 | 245 / 245 | 100% | 41.51 | 502 / 502 |
thymus | 100% | 2922.83 | 653 / 653 | 100% | 42.17 | 605 / 605 |
uterus | 100% | 1524.73 | 170 / 170 | 100% | 30.36 | 459 / 459 |
brain | 100% | 1934.18 | 2640 / 2642 | 100% | 32.32 | 705 / 705 |
kidney | 100% | 1828.89 | 89 / 89 | 100% | 26.51 | 899 / 901 |
stomach | 100% | 1771.74 | 359 / 359 | 100% | 28.42 | 285 / 286 |
bladder | 100% | 1664.62 | 21 / 21 | 100% | 30.88 | 502 / 504 |
pancreas | 100% | 1651.64 | 328 / 328 | 99% | 26.10 | 177 / 178 |
intestine | 100% | 2071.64 | 966 / 966 | 99% | 30.88 | 524 / 527 |
ovary | 100% | 1663.53 | 180 / 180 | 99% | 18.60 | 427 / 430 |
adrenal gland | 100% | 1892.28 | 258 / 258 | 97% | 21.53 | 224 / 230 |
skin | 100% | 2522.07 | 1809 / 1809 | 92% | 19.21 | 436 / 472 |
adipose | 100% | 1529.01 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 19.70 | 29 / 29 |
spleen | 100% | 1955.52 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 27.29 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 32.47 | 1 / 1 |
blood vessel | 100% | 1390.12 | 1330 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 1219.69 | 846 / 861 | 0% | 0 | 0 / 0 |
muscle | 98% | 705.73 | 787 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 86% | 925.68 | 795 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 74% | 9.90 | 59 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0017121 | Biological process | plasma membrane phospholipid scrambling |
GO_0044830 | Biological process | modulation by host of viral RNA genome replication |
GO_0007399 | Biological process | nervous system development |
GO_0000045 | Biological process | autophagosome assembly |
GO_0032365 | Biological process | intracellular lipid transport |
GO_0044233 | Cellular component | mitochondria-associated endoplasmic reticulum membrane contact site |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0017128 | Molecular function | phospholipid scramblase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | TMEM41B |
Protein name | Transmembrane protein 41B (Protein stasimon) Transmembrane protein 41B |
Synonyms | KIAA0033 |
Description | FUNCTION: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes . Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine . Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly . In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required . Required for normal motor neuron development (By similarity). .; FUNCTION: (Microbial infection) Critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus . Required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles . . |
Accessions | ENST00000528080.6 [Q5BJD5-1] ENST00000524543.5 [Q5BJD5-2] ENST00000611268.4 [Q5BJD5-1] ENST00000527813.5 Q5BJD5 ENST00000533723.1 [Q5BJD5-3] E9PJ42 ENST00000299596.8 [Q5BJD5-1] |