TMEM30B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TMEM30B at tissue level.

III. Associated gene sets

GO_0140331Biological processaminophospholipid translocation
GO_0045332Biological processphospholipid translocation
GO_0015917Biological processaminophospholipid transport
GO_0070863Biological processpositive regulation of protein exit from endoplasmic reticulum
GO_1990531Cellular componentphospholipid-translocating ATPase complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0005515Molecular functionprotein binding
GO_0015247Molecular functionaminophospholipid flippase activity

IV. Literature review

[source]
Gene nameTMEM30B
Protein nameCell cycle control protein 50B (P4-ATPase flippase complex beta subunit TMEM30B) (Transmembrane protein 30B)
SynonymsCDC50B
DescriptionFUNCTION: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane. .

AccessionsQ3MIR4
ENST00000555868.2