TMEM163 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140882Biological processzinc export across plasma membrane
GO_0099180Biological processzinc ion import into synaptic vesicle
GO_0042552Biological processmyelination
GO_0031901Cellular componentearly endosome membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTMEM163
Protein nameTransmembrane protein 163
Synonyms
DescriptionFUNCTION: Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis . Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 . Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes . .

AccessionsQ8TC26
ENST00000281924.6 [Q8TC26-1]