TIMM22 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TIMM22 at tissue level.

III. Associated gene sets

GO_0071806Biological processprotein transmembrane transport
GO_0045039Biological processprotein insertion into mitochondrial inner membrane
GO_0042721Cellular componentTIM22 mitochondrial import inner membrane insertion complex
GO_0005743Cellular componentmitochondrial inner membrane
GO_0008320Molecular functionprotein transmembrane transporter activity
GO_0030943Molecular functionmitochondrion targeting sequence binding
GO_0005515Molecular functionprotein binding
GO_0140318Molecular functionprotein transporter activity

IV. Literature review

[source]
Gene nameTIMM22
Protein nameMitochondrial import inner membrane translocase subunit Tim22 (Testis-expressed protein 4)
SynonymsTIM22
TEX4
DescriptionFUNCTION: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). .

AccessionsENST00000327158.5
ENST00000617832.2
Q9Y584
ENST00000613269.2