TIGAR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002931Biological processresponse to ischemia
GO_0006096Biological processglycolytic process
GO_0006003Biological processfructose 2,6-bisphosphate metabolic process
GO_0010332Biological processresponse to gamma radiation
GO_0045739Biological processpositive regulation of DNA repair
GO_0019661Biological processglucose catabolic process to lactate via pyruvate
GO_0006974Biological processDNA damage response
GO_2000378Biological processnegative regulation of reactive oxygen species metabolic process
GO_0010666Biological processpositive regulation of cardiac muscle cell apoptotic process
GO_1902153Biological processregulation of response to DNA damage checkpoint signaling
GO_0043069Biological processnegative regulation of programmed cell death
GO_0072593Biological processreactive oxygen species metabolic process
GO_0045820Biological processnegative regulation of glycolytic process
GO_1903301Biological processpositive regulation of hexokinase activity
GO_1905857Biological processpositive regulation of pentose-phosphate shunt
GO_1901525Biological processnegative regulation of mitophagy
GO_1904024Biological processnegative regulation of glucose catabolic process to lactate via pyruvate
GO_0060576Biological processintestinal epithelial cell development
GO_0010659Biological processcardiac muscle cell apoptotic process
GO_0000423Biological processmitophagy
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0071456Biological processcellular response to hypoxia
GO_0071279Biological processcellular response to cobalt ion
GO_0043456Biological processregulation of pentose-phosphate shunt
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005634Cellular componentnucleus
GO_0004331Molecular functionfructose-2,6-bisphosphate 2-phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTIGAR
Protein nameChromosome 12 open reading frame 5, isoform CRA_b (TP53 induced glycolysis regulatory phosphatase)
Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase)
SynonymshCG_24961
C12orf5
DescriptionFUNCTION: Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate . Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production . Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death . Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity . In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation . Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner . Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses . Involved in intestinal tumor progression . .

AccessionsA0A0U1RQD1
ENST00000179259.6
ENST00000635110.1
Q9NQ88