THOC5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006406Biological processmRNA export from nucleus
GO_0008380Biological processRNA splicing
GO_0006397Biological processmRNA processing
GO_0030224Biological processmonocyte differentiation
GO_0060215Biological processprimitive hemopoiesis
GO_0000445Cellular componentTHO complex part of transcription export complex
GO_0005654Cellular componentnucleoplasm
GO_0000346Cellular componenttranscription export complex
GO_0000347Cellular componentTHO complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding

IV. Literature review

[source]
Gene nameTHOC5
Protein nameTHO complex subunit 5
THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90)
SynonymsC22orf19
KIAA0983
DescriptionFUNCTION: Acts as a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.; FUNCTION: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.

AccessionsC9JCL9
C9JXG5
ENST00000418021.1
F8WCP5
ENST00000414902.5
ENST00000440771.5
Q13769
ENST00000358079.8
ENST00000397872.5
F8WES8
C9JXU6
H7C441
ENST00000455450.5
ENST00000490103.6
H7C072
ENST00000397873.6
ENST00000442555.5
ENST00000397871.5
ENST00000428374.5
F5GZF3
ENST00000443089.5