TEX19 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TEX19 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TEX19 at tissue level.

III. Associated gene sets

GO_0010526Biological processretrotransposon silencing
GO_0007131Biological processreciprocal meiotic recombination
GO_0008584Biological processmale gonad development
GO_0007283Biological processspermatogenesis
GO_0030154Biological processcell differentiation
GO_0007140Biological processmale meiotic nuclear division
GO_0001890Biological processplacenta development
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0034584Molecular functionpiRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTEX19
Protein nameTestis-expressed protein 19
Synonyms
DescriptionFUNCTION: Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization . .

AccessionsENST00000333437.5
Q8NA77