TET3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006211Biological process5-methylcytosine catabolic process
GO_0006493Biological processprotein O-linked glycosylation
GO_0044029Biological processpositive regulation of gene expression via chromosomal CpG island demethylation
GO_0044727Biological processepigenetic programing of male pronucleus
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0001939Cellular componentfemale pronucleus
GO_0001940Cellular componentmale pronucleus
GO_0005694Cellular componentchromosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0008327Molecular functionmethyl-CpG binding
GO_0070579Molecular function5-methylcytosine dioxygenase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTET3
Protein nameMethylcytosine dioxygenase TET (EC 1.14.11.80)
Methylcytosine dioxygenase TET3 (EC 1.14.11.80)
Alternative protein TET3
SynonymsKIAA0401
DescriptionFUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization . Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes . In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT . Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG . .

FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. .

AccessionsENST00000305799.8
A0A5H1ZRP3
L8EBE0
ENST00000409262.8 [O43151-1]
O43151