TERB2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TERB2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TERB2 at tissue level.

III. Associated gene sets

GO_0070197Biological processmeiotic attachment of telomere to nuclear envelope
GO_0007130Biological processsynaptonemal complex assembly
GO_0007283Biological processspermatogenesis
GO_0048477Biological processoogenesis
GO_1990918Biological processdouble-strand break repair involved in meiotic recombination
GO_0045141Biological processmeiotic telomere clustering
GO_0007129Biological processhomologous chromosome pairing at meiosis
GO_0000781Cellular componentchromosome, telomeric region
GO_0005637Cellular componentnuclear inner membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTERB2
Protein nameTelomere repeat binding bouquet formation protein 2
Telomere repeats-binding bouquet formation protein 2
SynonymsC15orf43
DescriptionFUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. .

AccessionsENST00000557864.1
ENST00000559137.5
Q8NHR7
H0YKV2
H0YNH3
ENST00000340827.4