TERB1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TERB1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TERB1 at tissue level.

III. Associated gene sets

GO_0070197Biological processmeiotic attachment of telomere to nuclear envelope
GO_1990918Biological processdouble-strand break repair involved in meiotic recombination
GO_0045141Biological processmeiotic telomere clustering
GO_0007129Biological processhomologous chromosome pairing at meiosis
GO_0000781Cellular componentchromosome, telomeric region
GO_0070187Cellular componentshelterin complex
GO_0005637Cellular componentnuclear inner membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTERB1
Protein nameTelomere repeats-binding bouquet formation protein 1 (Coiled-coil domain-containing protein 79)
Telomere repeat binding bouquet formation protein 1
SynonymsCCDC79
DescriptionFUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity. .

AccessionsENST00000559050.1
ENST00000433154.6 [Q8NA31-1]
ENST00000559403.1
ENST00000313294.7 [Q8NA31-3]
ENST00000673664.1
J3KT78
A0A669KAY0
ENST00000558713.6 [Q8NA31-1]
J3KSG9
Q8NA31