TEN1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TEN1 at tissue level.

III. Associated gene sets

GO_0032211Biological processnegative regulation of telomere maintenance via telomerase
GO_0016233Biological processtelomere capping
GO_1990879Cellular componentCST complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0010521Molecular functiontelomerase inhibitor activity
GO_0042162Molecular functiontelomeric DNA binding
GO_0005515Molecular functionprotein binding
GO_0003697Molecular functionsingle-stranded DNA binding

IV. Literature review

[source]
Gene nameTEN1
Protein nameTelomeric pathways in association with Stn1 number 1
TEN1 subunit of CST complex
CST complex subunit TEN1 (Protein telomeric pathways with STN1 homolog) (Telomere length regulation protein TEN1 homolog)
SynonymsC17orf106
DescriptionFUNCTION: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation . However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha . The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins . .

AccessionsENST00000588202.5
ENST00000586891.1
ENST00000590676.1
Q86WV5
K7EJS2
K7EL09
ENST00000397640.6
K7EIL0
D3U720