TELO2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TELO2 at tissue level.

III. Associated gene sets

GO_0051083Biological process'de novo' cotranslational protein folding
GO_2000003Biological processpositive regulation of DNA damage checkpoint
GO_0050821Biological processprotein stabilization
GO_0000781Cellular componentchromosome, telomeric region
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0110078Cellular componentTTT Hsp90 cochaperone complex
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0044877Molecular functionprotein-containing complex binding
GO_0051879Molecular functionHsp90 protein binding
GO_0042162Molecular functiontelomeric DNA binding
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding
GO_0060090Molecular functionmolecular adaptor activity

IV. Literature review

[source]
Gene nameTELO2
Protein nameTelomere length regulation protein TEL2 homolog
Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2)
Telomere maintenance 2
SynonymsKIAA0683
DescriptionFUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. .

AccessionsENST00000262319.11
Q9Y4R8
ENST00000497339.6
H3BRS3
ENST00000567423.1
H3BU45