TECPR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901096Biological processregulation of autophagosome maturation
GO_0006914Biological processautophagy
GO_0016236Biological processmacroautophagy
GO_0097352Biological processautophagosome maturation
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000421Cellular componentautophagosome membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005765Cellular componentlysosomal membrane
GO_0005515Molecular functionprotein binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding

IV. Literature review

[source]
Gene nameTECPR1
Protein nameTectonin beta-propeller repeat containing 1
Tectonin beta-propeller repeat-containing protein 1
SynonymsKIAA1358
DescriptionFUNCTION: Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. .

AccessionsQ7Z6L1
C9JEV4
ENST00000415086.5
C9JUV4
ENST00000447648.7 [Q7Z6L1-1]
ENST00000423128.5
ENST00000420697.1
C9J2A1