TDRKH report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TDRKH at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TDRKH at tissue level.

III. Associated gene sets

GO_0034587Biological processpiRNA processing
GO_0009566Biological processfertilization
GO_0007283Biological processspermatogenesis
GO_0030719Biological processP granule organization
GO_0007140Biological processmale meiotic nuclear division
GO_0071546Cellular componentpi-body
GO_0005739Cellular componentmitochondrion
GO_0071547Cellular componentpiP-body
GO_0043186Cellular componentP granule
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTDRKH
Protein nameTudor and KH domain-containing protein (Tudor domain-containing protein 2)
Tudor and KH domain containing (cDNA, FLJ79178, highly similar to Tudor and KH domain-containing protein)
Tudor and KH domain containing
SynonymsTDRD2
hCG_16924
DescriptionFUNCTION: Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules. .

AccessionsENST00000526378.5
E9PKN8
Q5SZR4
ENST00000368825.7 [Q9Y2W6-3]
ENST00000458431.6 [Q9Y2W6-2]
ENST00000368827.10 [Q9Y2W6-2]
ENST00000530202.1
ENST00000368823.5
ENST00000368824.8 [Q9Y2W6-2]
B7ZAG4
ENST00000526413.5
ENST00000525790.5
E9PQX4
ENST00000368822.5 [Q9Y2W6-2]
Q9Y2W6