TDRD9 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TDRD9 at tissue level.

III. Associated gene sets

GO_0034587Biological processpiRNA processing
GO_0009566Biological processfertilization
GO_0007283Biological processspermatogenesis
GO_0141006Biological processpiRNA-mediated retrotransposon silencing by heterochromatin formation
GO_0007141Biological processmale meiosis I
GO_0030154Biological processcell differentiation
GO_0007140Biological processmale meiotic nuclear division
GO_0141007Biological processsiRNA-mediated retrotransposon silencing by heterochromatin formation
GO_0005622Cellular componentintracellular anatomical structure
GO_0071547Cellular componentpiP-body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004386Molecular functionhelicase activity
GO_0003724Molecular functionRNA helicase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTDRD9
Protein nameTudor domain containing 9
ATP-dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain-containing protein 9)
SynonymsC14orf75
DescriptionFUNCTION: ATP-binding RNA helicase required during spermatogenesis . Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4. .

AccessionsH0YJJ2
ENST00000409874.9 [Q8NDG6-1]
ENST00000557332.5
Q8NDG6