I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 5 studies | 23% ± 2% | |
| capillary endothelial cell | 3 studies | 26% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 5 studies | 23% ± 2% | |
| capillary endothelial cell | 3 studies | 26% ± 8% |
Insufficient scRNA-seq data for expression of TCF15 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| uterus | 70% | 46.46 | 119 / 170 | 63% | 5.01 | 290 / 459 |
| breast | 95% | 312.20 | 435 / 459 | 35% | 1.02 | 386 / 1118 |
| adrenal gland | 44% | 27.69 | 114 / 258 | 79% | 2.90 | 181 / 230 |
| bladder | 67% | 60.33 | 14 / 21 | 44% | 2.71 | 224 / 504 |
| esophagus | 66% | 140.17 | 948 / 1445 | 40% | 1.94 | 73 / 183 |
| kidney | 58% | 36.40 | 52 / 89 | 45% | 1.31 | 407 / 901 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.00 | 1 / 1 |
| heart | 100% | 598.74 | 859 / 861 | 0% | 0 | 0 / 0 |
| muscle | 100% | 258.15 | 800 / 803 | 0% | 0 | 0 / 0 |
| adipose | 98% | 325.55 | 1179 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 11% | 4.56 | 20 / 180 | 81% | 4.00 | 347 / 430 |
| thymus | 57% | 32.92 | 370 / 653 | 34% | 0.97 | 208 / 605 |
| brain | 64% | 38.96 | 1678 / 2642 | 21% | 0.44 | 146 / 705 |
| intestine | 67% | 72.00 | 650 / 966 | 14% | 0.31 | 75 / 527 |
| lung | 41% | 33.85 | 238 / 578 | 37% | 1.61 | 427 / 1155 |
| eye | 0% | 0 | 0 / 0 | 76% | 2.17 | 61 / 80 |
| stomach | 38% | 28.75 | 138 / 359 | 25% | 0.62 | 72 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 47% | 1.88 | 21 / 45 |
| liver | 3% | 1.58 | 7 / 226 | 43% | 0.83 | 174 / 406 |
| prostate | 31% | 16.89 | 75 / 245 | 12% | 0.25 | 60 / 502 |
| skin | 6% | 3.12 | 110 / 1809 | 36% | 1.41 | 169 / 472 |
| pancreas | 4% | 2.06 | 14 / 328 | 28% | 0.56 | 49 / 178 |
| blood vessel | 29% | 24.02 | 383 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 8% | 7.20 | 75 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.20 | 2 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| GO_0007498 | Biological process | mesoderm development |
| GO_0045198 | Biological process | establishment of epithelial cell apical/basal polarity |
| GO_0060231 | Biological process | mesenchymal to epithelial transition |
| GO_0032502 | Biological process | developmental process |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0048339 | Biological process | paraxial mesoderm development |
| GO_1902037 | Biological process | negative regulation of hematopoietic stem cell differentiation |
| GO_0050884 | Biological process | neuromuscular process controlling posture |
| GO_0036342 | Biological process | post-anal tail morphogenesis |
| GO_0019827 | Biological process | stem cell population maintenance |
| GO_0003016 | Biological process | respiratory system process |
| GO_1903053 | Biological process | regulation of extracellular matrix organization |
| GO_0048644 | Biological process | muscle organ morphogenesis |
| GO_0001756 | Biological process | somitogenesis |
| GO_0043583 | Biological process | ear development |
| GO_2000738 | Biological process | positive regulation of stem cell differentiation |
| GO_0048705 | Biological process | skeletal system morphogenesis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0090575 | Cellular component | RNA polymerase II transcription regulator complex |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0043425 | Molecular function | bHLH transcription factor binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0070888 | Molecular function | E-box binding |
| GO_0046983 | Molecular function | protein dimerization activity |
| Gene name | TCF15 |
| Protein name | TCF15 protein Transcription factor 15 (Basic helix-loop-helix) Transcription factor 15 (TCF-15) (Class A basic helix-loop-helix protein 40) (bHLHa40) (Paraxis) (Protein bHLH-EC2) |
| Synonyms | hCG_1818267 BHLHEC2 BHLHA40 |
| Description | FUNCTION: Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal. Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells. Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes. . |
| Accessions | Q6NVX3 A4LBB6 Q12870 ENST00000246080.4 |
