TBC1D23 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007420Biological processbrain development
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0099041Biological processvesicle tethering to Golgi
GO_0016192Biological processvesicle-mediated transport
GO_1990403Biological processembryonic brain development
GO_0031175Biological processneuron projection development
GO_0005802Cellular componenttrans-Golgi network
GO_0071203Cellular componentWASH complex
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTBC1D23
Protein nameTBC1 domain family member 23
TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1)
SynonymsNS4ATP1
DescriptionFUNCTION: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking . Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles . Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 . Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). .

AccessionsENST00000394144.9 [Q9NUY8-1]
C9JAM5
E9PGE5
ENST00000475134.1
ENST00000471098.1
C9IZ32
ENST00000344949.9 [Q9NUY8-2]
ENST00000485687.5
Q9NUY8