TASL report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TASL at tissue level.

III. Associated gene sets

GO_0045087Biological processinnate immune response
GO_0034157Biological processpositive regulation of toll-like receptor 7 signaling pathway
GO_0034121Biological processregulation of toll-like receptor signaling pathway
GO_0035751Biological processregulation of lysosomal lumen pH
GO_0034161Biological processpositive regulation of toll-like receptor 8 signaling pathway
GO_0045089Biological processpositive regulation of innate immune response
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005654Cellular componentnucleoplasm
GO_0036020Cellular componentendolysosome membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTASL
Protein nameTLR adapter interacting with SLC15A4 on the lysosome
SynonymsCXorf21
DescriptionFUNCTION: Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 . Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons . Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes . .

AccessionsQ9HAI6
ENST00000378962.4