TARBP2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TARBP2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TARBP2 at tissue level.

III. Associated gene sets

GO_0035196Biological processmiRNA processing
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0045070Biological processpositive regulation of viral genome replication
GO_1903798Biological processregulation of miRNA processing
GO_0031054Biological processpre-miRNA processing
GO_0006417Biological processregulation of translation
GO_0098795Biological processglobal gene silencing by mRNA cleavage
GO_0030422Biological processsiRNA processing
GO_0070922Biological processRISC complex assembly
GO_0070921Biological processregulation of siRNA processing
GO_0039532Biological processnegative regulation of cytoplasmic pattern recognition receptor signaling pathway
GO_0070920Biological processregulation of regulatory ncRNA processing
GO_0050689Biological processnegative regulation of defense response to virus by host
GO_0046782Biological processregulation of viral transcription
GO_0070578Cellular componentRISC-loading complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016442Cellular componentRISC complex
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0035197Molecular functionsiRNA binding
GO_0070883Molecular functionpre-miRNA binding
GO_0042802Molecular functionidentical protein binding
GO_0036002Molecular functionpre-mRNA binding
GO_0140311Molecular functionprotein sequestering activity
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameTARBP2
Protein nameRISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein)
RISC-loading complex subunit TARBP2
TARBP2 subunit of RISC loading complex
SynonymsTRBP
DescriptionFUNCTION: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity) . Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 . Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation . .; FUNCTION: (Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs . This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha . May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR . Mediates recruitment of FTSJ3 methyltransferase to HIV-1 RNA, leading to 2'-O-methylation of the viral genome, allowing HIV-1 to escape the innate immune system . .

FUNCTION: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. .

FUNCTION: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. .

AccessionsH3BV98
ENST00000550407.1
ENST00000552857.5
F8VZZ7
F8VSA1
ENST00000394357.6 [Q15633-2]
F8VP94
ENST00000550147.5
ENST00000549572.5
ENST00000552817.5
A8K3X2
A0AA34QVS4
F8VYK6
ENST00000710362.1
ENST00000549679.5
F8VZ57
ENST00000266987.7 [Q15633-1]
ENST00000548971.5
ENST00000551741.5
F8VTT7
F8VYK3
Q15633
ENST00000547064.5
F8VW32
ENST00000456234.6 [Q15633-2]