TAF8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0001833Biological processinner cell mass cell proliferation
GO_0051457Biological processmaintenance of protein location in nucleus
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0030154Biological processcell differentiation
GO_0001112Biological processDNA-templated transcription open complex formation
GO_0045598Biological processregulation of fat cell differentiation
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTAF8
Protein nameTATA-box binding protein associated factor 8
Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43)
Transcription initiation factor TFIID subunit 8 (TBP-associated factor 8)
SynonymsTBN
TAFII43
DescriptionFUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription . TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) . The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 . The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C . TAF8 is involved in forming the TFIID-B module, together with TAF5 . Mediates both basal and activator-dependent transcription . Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts . Required for the integration of TAF10 in the TAF complex . May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). .

AccessionsQ7Z7C8
ENST00000372978.7
ENST00000372977.8 [Q7Z7C8-1]
A0A8I5QL33
ENST00000372982.8 [Q7Z7C8-4]
B4DZU5
ENST00000465926.5
ENST00000687601.1
A0A8I5KTT0
ENST00000456846.6 [Q7Z7C8-2]
A0A0A0MRR3
ENST00000686229.1
A0A8I5KVM3
A0A8I5QJI2
ENST00000494547.5 [Q7Z7C8-4]
ENST00000687266.1
ENST00000685500.1
ENST00000688007.1
A0A8I5QL44
ENST00000686935.1
A0A8I5KXI2