TAF5L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043484Biological processregulation of RNA splicing
GO_0006282Biological processregulation of DNA repair
GO_0006366Biological processtranscription by RNA polymerase II
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_1904672Biological processregulation of somatic stem cell population maintenance
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0033276Cellular componenttranscription factor TFTC complex
GO_0140513Cellular componentnuclear protein-containing complex
GO_0000124Cellular componentSAGA complex
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0000123Cellular componenthistone acetyltransferase complex
GO_0005634Cellular componentnucleus
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTAF5L
Protein nameTAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (TAF5L) (PCAF-associated factor 65 beta) (PAF65-beta)
TATA-box binding protein associated factor 5 like
SynonymsPAF65B
DescriptionFUNCTION: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity). .

AccessionsO75529
Q5TDI7
ENST00000366674.1
ENST00000258281.7 [O75529-1]
ENST00000366675.3 [O75529-2]