TAF5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TAF5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TAF5 at tissue level.

III. Associated gene sets

GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0006282Biological processregulation of DNA repair
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006352Biological processDNA-templated transcription initiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0033276Cellular componenttranscription factor TFTC complex
GO_0005730Cellular componentnucleolus
GO_0015629Cellular componentactin cytoskeleton
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTAF5
Protein nameTATA-box binding protein associated factor 5
Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100)
SynonymsTAF2D
DescriptionFUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription . TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) . The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 . The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C . TAF5 is involved in two modules of TFIID, in TFIID-A together with TAF3 and TBP, and in TFIID-B with TAF8 . Involved in contacts between TFIID and TFIIF in the PIC . .

AccessionsA0A8I5KZ43
ENST00000690052.1
ENST00000684872.1
A0A8I5KNW4
ENST00000369839.4 [Q15542-1]
ENST00000692195.1 [Q15542-2]
Q15542