SZT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901668Biological processregulation of superoxide dismutase activity
GO_0042149Biological processcellular response to glucose starvation
GO_0021540Biological processcorpus callosum morphogenesis
GO_0061462Biological processprotein localization to lysosome
GO_0009791Biological processpost-embryonic development
GO_0043473Biological processpigmentation
GO_0034198Biological processcellular response to amino acid starvation
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0007417Biological processcentral nervous system development
GO_0140007Cellular componentKICSTOR complex
GO_1990130Cellular componentGATOR1 complex
GO_0005777Cellular componentperoxisome
GO_0061700Cellular componentGATOR2 complex
GO_0005765Cellular componentlysosomal membrane
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameSZT2
Protein nameSZT2 subunit of KICSTOR complex
KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog)
Protein SZT2
SynonymsC1orf84
KIAA0467
DescriptionFUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose . May play a role in the cellular response to oxidative stress (By similarity). .

AccessionsENST00000406439
Q5T011
ENST00000470139.1
ENST00000634258.3 [Q5T011-1]
A0A0C4DG05
ENST00000639852.1
ENST00000372450.8 [Q5T011-7]
ENST00000562955.2 [Q5T011-5]
A0A1W2PQY2
A0A1W2PRY5