SYT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048488Biological processsynaptic vesicle endocytosis
GO_0048791Biological processcalcium ion-regulated exocytosis of neurotransmitter
GO_1903861Biological processpositive regulation of dendrite extension
GO_0030154Biological processcell differentiation
GO_0070382Cellular componentexocytic vesicle
GO_0030424Cellular componentaxon
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0042584Cellular componentchromaffin granule membrane
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0005886Cellular componentplasma membrane
GO_0031045Cellular componentdense core granule
GO_0030276Molecular functionclathrin binding
GO_0000149Molecular functionSNARE binding
GO_0005509Molecular functioncalcium ion binding
GO_0005544Molecular functioncalcium-dependent phospholipid binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0005515Molecular functionprotein binding
GO_0043533Molecular functioninositol 1,3,4,5 tetrakisphosphate binding

IV. Literature review

[source]
Gene nameSYT2
Protein nameSynaptotagmin
Synaptotagmin-2 (Synaptotagmin II) (SytII)
Synonyms
DescriptionFUNCTION: Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes . .

FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. .

AccessionsA4FU00
ENST00000367267.5
Q8N9I0
ENST00000367268.5