SYNE3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008360Biological processregulation of cell shape
GO_0090150Biological processestablishment of protein localization to membrane
GO_0007010Biological processcytoskeleton organization
GO_0007097Biological processnuclear migration
GO_0034993Cellular componentmeiotic nuclear membrane microtubule tethering complex
GO_0005791Cellular componentrough endoplasmic reticulum
GO_0031965Cellular componentnuclear membrane
GO_0005640Cellular componentnuclear outer membrane
GO_0005635Cellular componentnuclear envelope
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0140444Molecular functioncytoskeleton-nuclear membrane anchor activity
GO_0051015Molecular functionactin filament binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSYNE3
Protein nameNesprin-3 (KASH domain-containing protein 3) (KASH3) (Nuclear envelope spectrin repeat protein 3)
Spectrin repeat containing nuclear envelope family member 3
SynonymsC14orf139
LINC00341
C14orf49
DescriptionFUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. .

AccessionsQ6ZMZ3
ENST00000554873.5
ENST00000334258.9 [Q6ZMZ3-1]
G3V533
ENST00000682763.1 [Q6ZMZ3-1]
ENST00000553340.1 [Q6ZMZ3-3]
ENST00000557275.5 [Q6ZMZ3-2]