SULT2B1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SULT2B1 at tissue level.

III. Associated gene sets

GO_0045606Biological processpositive regulation of epidermal cell differentiation
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0008203Biological processcholesterol metabolic process
GO_0051923Biological processsulfation
GO_0050427Biological process3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO_0008202Biological processsteroid metabolic process
GO_0070062Cellular componentextracellular exosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0051922Molecular functioncholesterol sulfotransferase activity
GO_0050294Molecular functionsteroid sulfotransferase activity
GO_0015485Molecular functioncholesterol binding
GO_0003676Molecular functionnucleic acid binding
GO_0036094Molecular functionsmall molecule binding
GO_0008146Molecular functionsulfotransferase activity
GO_0005515Molecular functionprotein binding
GO_1990239Molecular functionsteroid hormone binding

IV. Literature review

[source]
Gene nameSULT2B1
Protein nameSulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1)
SynonymsHSST2
DescriptionFUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol . Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) . Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA . Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation . .; FUNCTION: [Isoform 2]: Sulfonates pregnenolone but not cholesterol. .

AccessionsENST00000323090.4 [O00204-2]
O00204
ENST00000201586.7 [O00204-1]