Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| plasmacytoid dendritic cell | 9 studies | 25% ± 7% | |
| plasma cell | 7 studies | 37% ± 16% | |
| plasmablast | 6 studies | 45% ± 28% | |
| epithelial cell | 5 studies | 36% ± 19% | |
| goblet cell | 5 studies | 24% ± 7% | |
| fibroblast | 4 studies | 22% ± 5% | |
| ciliated cell | 4 studies | 21% ± 5% | |
| dendritic cell | 4 studies | 23% ± 5% | |
| endothelial cell | 3 studies | 18% ± 2% | |
| myeloid cell | 3 studies | 21% ± 2% | |
| GABAergic neuron | 3 studies | 21% ± 2% | |
| glutamatergic neuron | 3 studies | 24% ± 3% | |
| abnormal cell | 3 studies | 25% ± 13% | |
| IgA plasma cell | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 5144.84 | 459 / 459 | 100% | 97.86 | 1118 / 1118 |
| intestine | 100% | 4517.24 | 966 / 966 | 100% | 84.11 | 527 / 527 |
| liver | 100% | 4093.24 | 226 / 226 | 100% | 64.23 | 406 / 406 |
| lung | 100% | 5522.02 | 578 / 578 | 100% | 83.70 | 1155 / 1155 |
| ovary | 100% | 7117.39 | 180 / 180 | 100% | 61.62 | 430 / 430 |
| pancreas | 100% | 6401.96 | 328 / 328 | 100% | 68.07 | 178 / 178 |
| prostate | 100% | 4657.37 | 245 / 245 | 100% | 117.75 | 502 / 502 |
| stomach | 100% | 4329.08 | 359 / 359 | 100% | 77.66 | 286 / 286 |
| esophagus | 100% | 3684.20 | 1444 / 1445 | 100% | 57.16 | 183 / 183 |
| thymus | 100% | 6010.81 | 653 / 653 | 100% | 73.74 | 603 / 605 |
| bladder | 100% | 5016.33 | 21 / 21 | 100% | 76.69 | 502 / 504 |
| uterus | 100% | 7114.28 | 170 / 170 | 99% | 70.15 | 456 / 459 |
| skin | 100% | 7729.49 | 1808 / 1809 | 99% | 79.21 | 468 / 472 |
| kidney | 100% | 3537.18 | 89 / 89 | 99% | 61.78 | 888 / 901 |
| brain | 97% | 1995.28 | 2559 / 2642 | 100% | 46.54 | 703 / 705 |
| adrenal gland | 100% | 5295.07 | 258 / 258 | 95% | 46.83 | 219 / 230 |
| adipose | 100% | 4911.67 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5431.18 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 77.60 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 57.76 | 29 / 29 |
| spleen | 100% | 5105.71 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 49.14 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 29.69 | 1 / 1 |
| heart | 97% | 3275.88 | 838 / 861 | 0% | 0 | 0 / 0 |
| muscle | 94% | 1552.29 | 753 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 86% | 3412.56 | 798 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0018279 | Biological process | protein N-linked glycosylation via asparagine |
| GO_0006487 | Biological process | protein N-linked glycosylation |
| GO_0043687 | Biological process | post-translational protein modification |
| GO_0043686 | Biological process | co-translational protein modification |
| GO_0008250 | Cellular component | oligosaccharyltransferase complex |
| GO_0035000 | Cellular component | oligosaccharyltransferase III complex |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0004579 | Molecular function | dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | STT3A |
| Protein name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (EC 2.4.99.18) Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) (B5) (Integral membrane protein 1) (Transmembrane protein TMC) |
| Synonyms | ITM1 TMC |
| Description | FUNCTION: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation . N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A . . |
| Accessions | ENST00000529196.5 [P46977-1] P46977 ENST00000527606.5 ENST00000529886.1 ENST00000392708.9 [P46977-1] ENST00000525652.5 A0A0C4DH80 ENST00000531491.5 [P46977-2] ENST00000649491.1 [P46977-1] E9PI32 H0YET6 E9PN73 ENST00000526726.1 |