Name | Number of supported studies | Average coverage | |
---|---|---|---|
retinal pigment epithelial cell | 5 studies | 39% ± 9% |
Insufficient scRNA-seq data for expression of STRA6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
uterus | 89% | 1930.49 | 152 / 170 | 66% | 16.79 | 302 / 459 |
ovary | 77% | 141.82 | 138 / 180 | 76% | 12.18 | 326 / 430 |
prostate | 100% | 1498.43 | 245 / 245 | 50% | 3.31 | 250 / 502 |
adrenal gland | 72% | 217.00 | 187 / 258 | 57% | 70.49 | 131 / 230 |
bladder | 81% | 303.43 | 17 / 21 | 48% | 6.56 | 244 / 504 |
breast | 61% | 221.26 | 280 / 459 | 61% | 4.05 | 678 / 1118 |
esophagus | 66% | 115.06 | 954 / 1445 | 55% | 8.66 | 100 / 183 |
thymus | 41% | 30.65 | 265 / 653 | 65% | 11.79 | 395 / 605 |
kidney | 98% | 782.48 | 87 / 89 | 4% | 0.42 | 39 / 901 |
pancreas | 18% | 20.25 | 60 / 328 | 83% | 14.23 | 147 / 178 |
skin | 45% | 51.65 | 823 / 1809 | 42% | 14.44 | 197 / 472 |
lung | 35% | 53.71 | 204 / 578 | 51% | 7.37 | 586 / 1155 |
tonsil | 0% | 0 | 0 / 0 | 69% | 9.39 | 31 / 45 |
lymph node | 0% | 0 | 0 / 0 | 66% | 4.10 | 19 / 29 |
intestine | 21% | 19.32 | 201 / 966 | 41% | 6.69 | 217 / 527 |
stomach | 4% | 2.39 | 13 / 359 | 43% | 6.00 | 124 / 286 |
blood vessel | 39% | 44.80 | 523 / 1335 | 0% | 0 | 0 / 0 |
spleen | 37% | 20.64 | 88 / 241 | 0% | 0 | 0 / 0 |
brain | 25% | 20.92 | 665 / 2642 | 11% | 1.11 | 79 / 705 |
adipose | 20% | 19.93 | 245 / 1204 | 0% | 0 | 0 / 0 |
heart | 17% | 9.36 | 143 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 12% | 19.54 | 113 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 6% | 0.49 | 5 / 80 |
liver | 1% | 0.87 | 2 / 226 | 5% | 0.61 | 19 / 406 |
muscle | 0% | 0.15 | 3 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0048844 | Biological process | artery morphogenesis |
GO_0061205 | Biological process | paramesonephric duct development |
GO_0030324 | Biological process | lung development |
GO_0060322 | Biological process | head development |
GO_0061143 | Biological process | alveolar primary septum development |
GO_0030540 | Biological process | female genitalia development |
GO_0042297 | Biological process | vocal learning |
GO_0043585 | Biological process | nose morphogenesis |
GO_0007612 | Biological process | learning |
GO_0007507 | Biological process | heart development |
GO_0007631 | Biological process | feeding behavior |
GO_0048566 | Biological process | embryonic digestive tract development |
GO_0061038 | Biological process | uterus morphogenesis |
GO_0001822 | Biological process | kidney development |
GO_0003281 | Biological process | ventricular septum development |
GO_0048520 | Biological process | positive regulation of behavior |
GO_0050905 | Biological process | neuromuscular process |
GO_0060539 | Biological process | diaphragm development |
GO_0060426 | Biological process | lung vasculature development |
GO_0060900 | Biological process | embryonic camera-type eye formation |
GO_0071939 | Biological process | vitamin A import into cell |
GO_0030325 | Biological process | adrenal gland development |
GO_0001568 | Biological process | blood vessel development |
GO_0061156 | Biological process | pulmonary artery morphogenesis |
GO_0097070 | Biological process | ductus arteriosus closure |
GO_0050890 | Biological process | cognition |
GO_0003184 | Biological process | pulmonary valve morphogenesis |
GO_0043010 | Biological process | camera-type eye development |
GO_0048589 | Biological process | developmental growth |
GO_0043583 | Biological process | ear development |
GO_0060323 | Biological process | head morphogenesis |
GO_0060325 | Biological process | face morphogenesis |
GO_0048546 | Biological process | digestive tract morphogenesis |
GO_0061029 | Biological process | eyelid development in camera-type eye |
GO_0048745 | Biological process | smooth muscle tissue development |
GO_0048286 | Biological process | lung alveolus development |
GO_0034633 | Biological process | retinol transport |
GO_0005886 | Cellular component | plasma membrane |
GO_0032991 | Cellular component | protein-containing complex |
GO_0038023 | Molecular function | signaling receptor activity |
GO_0034632 | Molecular function | retinol transmembrane transporter activity |
GO_0019841 | Molecular function | retinol binding |
GO_0016918 | Molecular function | retinal binding |
Gene name | STRA6 |
Protein name | Receptor for retinol uptake STRA6 (Retinol-binding protein receptor STRA6) (Stimulated by retinoic acid gene 6 protein homolog) Signaling receptor and transporter of retinol STRA6 Alternative protein STRA6 Receptor for retinol uptake STRA6 (Retinol-binding protein receptor STRA6) |
Synonyms | PP14296 UNQ3126/PRO10282/PRO19578 |
Description | FUNCTION: Functions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 . Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A . Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin . Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid . STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid . . |
Accessions | ENST00000574278.5 [Q9BX79-6] L8E774 ENST00000569936.5 ENST00000673241.1 [Q9BX79-4] I3L1C7 ENST00000395105.9 [Q9BX79-1] ENST00000673039.1 [Q9BX79-6] ENST00000535552.5 [Q9BX79-5] ENST00000672446.1 [Q9BX79-3] ENST00000673519.1 [Q9BX79-2] I3NI08 ENST00000432245.6 [Q9BX79-2] ENST00000673414.1 [Q9BX79-1] ENST00000572785.1 ENST00000323940.9 [Q9BX79-1] Q9BX79 ENST00000423167.6 [Q9BX79-3] ENST00000563965.5 [Q9BX79-4] ENST00000672584.1 [Q9BX79-1] ENST00000416286.7 ENST00000673026.1 [Q9BX79-1] I3L0M6 ENST00000672836.1 [Q9BX79-5] ENST00000672526.1 [Q9BX79-1] J3KQI6 ENST00000449139.6 [Q9BX79-1] I3L2B6 ENST00000616000.4 [Q9BX79-1] ENST00000573391.1 ENST00000571341.1 |