STK16 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of STK16 at tissue level.

III. Associated gene sets

GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0046777Biological processprotein autophosphorylation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005798Cellular componentGolgi-associated vesicle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005737Cellular componentcytoplasm
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0106310Molecular functionprotein serine kinase activity

IV. Literature review

[source]
Gene nameSTK16
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) (hPSK)
SynonymsMPSK1
TSF1
PKL12
DescriptionFUNCTION: Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. .

AccessionsB8ZZN3
ENST00000409743.1
B8ZZI5
B4DPS1
ENST00000409516.7
ENST00000396738.7
ENST00000409260.5
O75716
ENST00000409638.7