STIMATE report

I. Expression across cell types

Insufficient scRNA-seq data for expression of STIMATE at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of STIMATE at tissue level.

III. Associated gene sets

GO_0032237Biological processactivation of store-operated calcium channel activity
GO_0002115Biological processstore-operated calcium entry
GO_0032541Cellular componentcortical endoplasmic reticulum
GO_0140268Cellular componentendoplasmic reticulum-plasma membrane contact site
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005246Molecular functioncalcium channel regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSTIMATE
Protein nameStore-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110)
STIM activating enhancer
SynonymsTMEM110
DescriptionFUNCTION: Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER . SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores . Acts by interacting with STIM1, promoting STIM1 conformational switch . Involved in STIM1 relocalization to ER-PM junctions . Contributes to the maintenance and reorganization of store-dependent ER-PM junctions . .

AccessionsF8WDI5
ENST00000467979.1
ENST00000355083.11
Q86TL2
H7C551
H7C503
ENST00000485356.1
ENST00000482155.1