STEAP4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of STEAP4 at tissue level.

III. Associated gene sets

GO_0015677Biological processcopper ion import
GO_0070207Biological processprotein homotrimerization
GO_0033212Biological processiron import into cell
GO_0045444Biological processfat cell differentiation
GO_0031901Cellular componentearly endosome membrane
GO_0000139Cellular componentGolgi membrane
GO_0070062Cellular componentextracellular exosome
GO_0005768Cellular componentendosome
GO_0005654Cellular componentnucleoplasm
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0008823Molecular functioncupric reductase (NADH) activity
GO_0052851Molecular functionferric-chelate reductase (NADPH) activity
GO_0071949Molecular functionFAD binding
GO_0020037Molecular functionheme binding
GO_0046872Molecular functionmetal ion binding
GO_0009055Molecular functionelectron transfer activity

IV. Literature review

[source]
Gene nameSTEAP4
Protein nameMetalloreductase STEAP4 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9)
STEAP4 metalloreductase
SynonymsTNFAIP9
STAMP2
DescriptionFUNCTION: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate . Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance . Involved in inflammatory arthritis, through the regulation of inflammatory cytokines . Inhibits anchorage-independent cell proliferation . .

AccessionsENST00000414498.1
ENST00000301959.9 [Q687X5-2]
Q687X5
ENST00000380079.9 [Q687X5-1]
C9JS50