Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pericyte | 14 studies | 37% ± 15% | |
| type II pneumocyte | 10 studies | 40% ± 14% | |
| club cell | 10 studies | 34% ± 16% | |
| respiratory goblet cell | 8 studies | 39% ± 16% | |
| smooth muscle cell | 8 studies | 29% ± 7% | |
| fibroblast | 6 studies | 26% ± 13% | |
| duct epithelial cell | 4 studies | 28% ± 13% | |
| epithelial cell | 4 studies | 32% ± 11% | |
| secretory cell | 4 studies | 34% ± 15% | |
| type I pneumocyte | 3 studies | 22% ± 5% | |
| squamous epithelial cell | 3 studies | 52% ± 16% | |
| hepatic stellate cell | 3 studies | 21% ± 3% | |
| ciliated cell | 3 studies | 18% ± 1% | |
| luminal cell of prostate epithelium | 3 studies | 17% ± 2% |
Insufficient scRNA-seq data for expression of STEAP4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 96% | 6738.75 | 235 / 245 | 100% | 115.77 | 500 / 502 |
| thymus | 100% | 15328.10 | 652 / 653 | 79% | 12.49 | 479 / 605 |
| breast | 100% | 18686.46 | 458 / 459 | 60% | 19.69 | 671 / 1118 |
| lung | 79% | 5524.75 | 459 / 578 | 65% | 24.16 | 754 / 1155 |
| adrenal gland | 99% | 14089.20 | 255 / 258 | 37% | 4.49 | 84 / 230 |
| uterus | 87% | 5539.42 | 148 / 170 | 44% | 12.40 | 201 / 459 |
| esophagus | 84% | 4796.94 | 1221 / 1445 | 45% | 7.66 | 83 / 183 |
| bladder | 86% | 5116.19 | 18 / 21 | 27% | 4.62 | 135 / 504 |
| pancreas | 40% | 1252.89 | 131 / 328 | 66% | 6.52 | 117 / 178 |
| adipose | 100% | 25364.94 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| skin | 75% | 5053.51 | 1354 / 1809 | 17% | 1.48 | 78 / 472 |
| kidney | 45% | 1870.11 | 40 / 89 | 46% | 7.34 | 417 / 901 |
| heart | 87% | 4795.29 | 750 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 82% | 7266.32 | 1093 / 1335 | 0% | 0 | 0 / 0 |
| liver | 59% | 3305.82 | 134 / 226 | 15% | 1.80 | 62 / 406 |
| intestine | 60% | 2920.88 | 582 / 966 | 14% | 1.61 | 73 / 527 |
| stomach | 46% | 2178.74 | 164 / 359 | 17% | 1.91 | 49 / 286 |
| muscle | 53% | 1721.52 | 427 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 50% | 5954.94 | 461 / 929 | 0% | 0 | 0 / 0 |
| spleen | 34% | 1071.24 | 81 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 27% | 2.21 | 12 / 45 |
| ovary | 12% | 812.98 | 22 / 180 | 12% | 1.01 | 53 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.44 | 2 / 29 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.06 | 1 / 80 |
| brain | 0% | 0.93 | 1 / 2642 | 1% | 0.07 | 7 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0015677 | Biological process | copper ion import |
| GO_0070207 | Biological process | protein homotrimerization |
| GO_0033212 | Biological process | iron import into cell |
| GO_0045444 | Biological process | fat cell differentiation |
| GO_0031901 | Cellular component | early endosome membrane |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005768 | Cellular component | endosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0008823 | Molecular function | cupric reductase (NADH) activity |
| GO_0052851 | Molecular function | ferric-chelate reductase (NADPH) activity |
| GO_0071949 | Molecular function | FAD binding |
| GO_0020037 | Molecular function | heme binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0009055 | Molecular function | electron transfer activity |
| Gene name | STEAP4 |
| Protein name | Metalloreductase STEAP4 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9) STEAP4 metalloreductase |
| Synonyms | TNFAIP9 STAMP2 |
| Description | FUNCTION: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate . Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance . Involved in inflammatory arthritis, through the regulation of inflammatory cytokines . Inhibits anchorage-independent cell proliferation . . |
| Accessions | ENST00000414498.1 ENST00000301959.9 [Q687X5-2] Q687X5 ENST00000380079.9 [Q687X5-1] C9JS50 |