SS18L1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0016358Biological processdendrite development
GO_0050775Biological processpositive regulation of dendrite morphogenesis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000776Cellular componentkinetochore
GO_0071565Cellular componentnBAF complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSS18L1
Protein nameCalcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1)
SS18L1 subunit of BAF chromatin remodeling complex
SynonymsCREST
KIAA0693
DescriptionFUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). .

AccessionsH0YDW4
Q9BR54
ENST00000492466.2
ENST00000450482.5
ENST00000370848.8 [O75177-3]
O75177
ENST00000331758.8 [O75177-1]