SRGAP2C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0021816Biological processextension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
GO_1904862Biological processinhibitory synapse assembly
GO_0021987Biological processcerebral cortex development
GO_1904861Biological processexcitatory synapse assembly
GO_0051490Biological processnegative regulation of filopodium assembly
GO_0051963Biological processregulation of synapse assembly
GO_0061000Biological processnegative regulation of dendritic spine development
GO_2001224Biological processpositive regulation of neuron migration
GO_0098978Cellular componentglutamatergic synapse
GO_0046982Molecular functionprotein heterodimerization activity
GO_0042803Molecular functionprotein homodimerization activity

IV. Literature review

[source]
Gene nameSRGAP2C
Protein nameSLIT-ROBO Rho GTPase-activating protein 2C (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1)
SLIT-ROBO Rho GTPase activating protein 2C
SynonymsSRGAP2P1
DescriptionFUNCTION: Human-specific protein that acts as a key modifier of cortical connectivity in the human brain . Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons . SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation . Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to an increase in synaptic density and protracted synaptic maturation of both excitatory and inhibitory synapses . Modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons . Also able to increase the probability of sensory-evoked responses by layer 2/3 pyramidal neurons . .

AccessionsENST00000367123.8
ENST00000304465.7
A0A087X0L1
P0DJJ0