SPPL2C | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPPL2C at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	57%	42.18	1511 / 2642	1%	0.02	10 / 705
breast	11%	4.05	51 / 459	2%	0.03	22 / 1118
prostate	3%	2.91	7 / 245	0%	0	0 / 502
thymus	2%	0.89	10 / 653	0%	0	0 / 605
intestine	1%	0.30	10 / 966	0%	0.01	1 / 527
liver	1%	0.19	2 / 226	0%	0	0 / 406
stomach	1%	0.16	3 / 359	0%	0	0 / 286
skin	1%	0.50	15 / 1809	0%	0	0 / 472
adrenal gland	0%	0.37	1 / 258	0%	0.00	1 / 230
uterus	1%	0.09	1 / 170	0%	0	0 / 459
adipose	1%	0.19	7 / 1204	0%	0	0 / 0
muscle	0%	0.73	4 / 803	0%	0	0 / 0
pancreas	0%	0.04	1 / 328	0%	0	0 / 178
blood vessel	0%	0.07	4 / 1335	0%	0	0 / 0
esophagus	0%	0.56	4 / 1445	0%	0	0 / 183
lung	0%	0.12	1 / 578	0%	0	0 / 1155
heart	0%	0.03	1 / 861	0%	0	0 / 0
peripheral blood	0%	0.01	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bladder	0%	0	0 / 21	0%	0	0 / 504
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
kidney	0%	0	0 / 89	0%	0	0 / 901
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
ovary	0%	0	0 / 180	0%	0	0 / 430
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0033619	Biological process	membrane protein proteolysis
GO_0031293	Biological process	membrane protein intracellular domain proteolysis
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0035036	Biological process	sperm-egg recognition
GO_0001675	Biological process	acrosome assembly
GO_0007342	Biological process	fusion of sperm to egg plasma membrane involved in single fertilization
GO_0006509	Biological process	membrane protein ectodomain proteolysis
GO_0030660	Cellular component	Golgi-associated vesicle membrane
GO_0098553	Cellular component	lumenal side of endoplasmic reticulum membrane
GO_0098554	Cellular component	cytoplasmic side of endoplasmic reticulum membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0042803	Molecular function	protein homodimerization activity
GO_0005515	Molecular function	protein binding
GO_0042500	Molecular function	aspartic endopeptidase activity, intramembrane cleaving
GO_0060090	Molecular function	molecular adaptor activity

Gene name	SPPL2C
Protein name	Signal peptide peptidase-like 2C Signal peptide peptidase-like 2C (SPP-like 2C) (SPPL2c) (EC 3.4.23.-) (Intramembrane protease 5) (IMP-5)
Synonyms	IMP5
Description	FUNCTION: Sperm-specific intramembrane-cleaving aspartic protease (I-CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins . In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage (By similarity). During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome . .; FUNCTION: In round spermatids, acts as a scaffold protein supporting FREY1 in IZUMO1 recruitment at the endoplasmic reticulum membrane and coordination of IZUMO1 complex assembly. Stabilizes FREY1 at the endoplasmic reticulum membrane through interaction. May recruit IZUMO1 interaction partners. .
Accessions	A0A0G2JNG8 A0A0G2JPF3 ENST00000610319.2 Q8IUH8 ENST00000329196.7 ENST00000621383.2

SPPL2C report