Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| platelet | 7 studies | 23% ± 5% | |
| mast cell | 6 studies | 20% ± 5% | |
| macrophage | 5 studies | 25% ± 6% | |
| classical monocyte | 5 studies | 27% ± 8% | |
| conventional dendritic cell | 5 studies | 30% ± 15% | |
| epithelial cell | 5 studies | 29% ± 14% | |
| non-classical monocyte | 4 studies | 28% ± 8% | |
| megakaryocyte | 3 studies | 36% ± 14% | |
| dendritic cell | 3 studies | 41% ± 9% | |
| monocyte | 3 studies | 19% ± 5% | |
| alveolar macrophage | 3 studies | 23% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 2699.90 | 89 / 89 | 27% | 0.43 | 242 / 901 |
| brain | 99% | 1435.50 | 2619 / 2642 | 22% | 0.31 | 155 / 705 |
| skin | 100% | 3055.58 | 1809 / 1809 | 20% | 0.30 | 96 / 472 |
| lung | 100% | 3362.50 | 578 / 578 | 19% | 0.27 | 216 / 1155 |
| esophagus | 100% | 2619.06 | 1445 / 1445 | 16% | 0.21 | 30 / 183 |
| ovary | 100% | 2177.73 | 180 / 180 | 14% | 0.21 | 62 / 430 |
| pancreas | 100% | 1269.11 | 328 / 328 | 13% | 0.17 | 24 / 178 |
| breast | 100% | 2612.75 | 459 / 459 | 13% | 0.19 | 144 / 1118 |
| bladder | 100% | 3088.90 | 21 / 21 | 12% | 0.17 | 60 / 504 |
| intestine | 100% | 3059.17 | 966 / 966 | 11% | 0.14 | 57 / 527 |
| stomach | 100% | 2190.94 | 359 / 359 | 9% | 0.11 | 26 / 286 |
| uterus | 100% | 3102.84 | 170 / 170 | 7% | 0.11 | 32 / 459 |
| thymus | 100% | 3125.70 | 653 / 653 | 6% | 0.08 | 35 / 605 |
| liver | 100% | 1605.23 | 226 / 226 | 6% | 0.08 | 23 / 406 |
| adrenal gland | 100% | 2724.78 | 258 / 258 | 5% | 0.06 | 11 / 230 |
| prostate | 100% | 2871.34 | 245 / 245 | 1% | 0.01 | 4 / 502 |
| adipose | 100% | 2601.23 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3215.14 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3446.26 | 241 / 241 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1365.44 | 801 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 1354.18 | 851 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 1598.68 | 908 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 11% | 0.16 | 9 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 0.05 | 2 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0035751 | Biological process | regulation of lysosomal lumen pH |
| GO_0051977 | Biological process | lysophospholipid transport |
| GO_0033700 | Biological process | phospholipid efflux |
| GO_0055085 | Biological process | transmembrane transport |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0005215 | Molecular function | transporter activity |
| GO_0022857 | Molecular function | transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SPNS1 |
| Protein name | Protein spinster homolog 1 (Spns1) Protein spinster homolog 1 (HSpin1) (SPNS1) (Spinster-like protein 1) SPNS lysolipid transporter 1, lysophospholipid |
| Synonyms | PP20300 hCG_2002366 SPIN1 |
| Description | FUNCTION: Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol . Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids . Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin . Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3-phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively . Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine . Lysosomal LPC could function as intracellular signaling messenger . Essential player in lysosomal homeostasis . Crucial for cell survival under conditions of nutrient limitation . May be involved in necrotic or autophagic cell death . . |
| Accessions | Q9H2V7 H3BR82 ENST00000565975.5 ENST00000564476.1 ENST00000334536.12 [Q9H2V7-2] H3BP14 ENST00000352260.11 [Q9H2V7-3] H3BPT8 ENST00000567771.5 ENST00000311008.16 [Q9H2V7-1] H3BPQ9 H3BMF4 ENST00000566059.5 ENST00000568388.5 H3BT44 ENST00000568829.1 ENST00000323081.12 [Q9H2V7-4] |
