SPINK2 | OmnibusX

Name	Number of supported studies	Average coverage
hematopoietic stem cell	8 studies	66% ± 9%	Explore
hematopoietic precursor cell	4 studies	67% ± 12%	Explore
group 3 innate lymphoid cell	4 studies	35% ± 10%	Explore
innate lymphoid cell	3 studies	28% ± 9%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPINK2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	71%	18.57	462 / 653	95%	8.84	577 / 605
ureter	0%	0	0 / 0	100%	11.12	1 / 1
spleen	95%	48.76	228 / 241	0%	0	0 / 0
prostate	69%	84.38	168 / 245	25%	1.37	125 / 502
lung	31%	4.96	179 / 578	55%	3.73	640 / 1155
lymph node	0%	0	0 / 0	83%	33.31	24 / 29
breast	56%	22.24	259 / 459	24%	0.67	266 / 1118
intestine	57%	31.32	554 / 966	23%	1.14	119 / 527
uterus	32%	8.61	55 / 170	35%	1.26	160 / 459
bladder	38%	12.00	8 / 21	28%	2.92	140 / 504
brain	50%	9.40	1308 / 2642	14%	0.40	99 / 705
ovary	24%	9.62	44 / 180	39%	1.10	168 / 430
stomach	45%	12.62	161 / 359	19%	0.51	53 / 286
muscle	58%	28.14	466 / 803	0%	0	0 / 0
heart	53%	69.10	459 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	47%	1.86	21 / 45
skin	32%	5.73	579 / 1809	14%	0.52	66 / 472
pancreas	14%	1.63	45 / 328	32%	0.99	57 / 178
kidney	26%	6.83	23 / 89	17%	1.26	154 / 901
esophagus	16%	3.81	229 / 1445	27%	1.10	49 / 183
peripheral blood	43%	10.64	395 / 929	0%	0	0 / 0
adipose	39%	13.23	471 / 1204	0%	0	0 / 0
blood vessel	25%	17.53	332 / 1335	0%	0	0 / 0
adrenal gland	10%	1.83	27 / 258	10%	0.42	22 / 230
liver	5%	1.75	11 / 226	1%	0.07	6 / 406
eye	0%	0	0 / 0	3%	0.06	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_1900004	Biological process	negative regulation of serine-type endopeptidase activity
GO_0001675	Biological process	acrosome assembly
GO_0007286	Biological process	spermatid development
GO_0001669	Cellular component	acrosomal vesicle
GO_0005576	Cellular component	extracellular region
GO_0004866	Molecular function	endopeptidase inhibitor activity
GO_0004867	Molecular function	serine-type endopeptidase inhibitor activity
GO_0005515	Molecular function	protein binding

Gene name	SPINK2
Protein name	Serine protease inhibitor Kazal-type 2 (Acrosin-trypsin inhibitor) (Epididymis tissue protein Li 172) (HUSI-II) Serine peptidase inhibitor Kazal type 2
Synonyms
Description	FUNCTION: As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects . May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin. .
Accessions	D6RC51 A0A087WTA9 A0AA34QVT9 ENST00000506738.6 ENST00000618802.3 ENST00000707144.1 D6RI10 ENST00000248701.8 P20155 ENST00000504762.1

SPINK2 report