SPINK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050732Biological processnegative regulation of peptidyl-tyrosine phosphorylation
GO_0031667Biological processresponse to nutrient levels
GO_0090187Biological processpositive regulation of pancreatic juice secretion
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0060046Biological processregulation of acrosome reaction
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0048240Biological processsperm capacitation
GO_2001256Biological processregulation of store-operated calcium entry
GO_0071375Biological processcellular response to peptide hormone stimulus
GO_0007263Biological processnitric oxide mediated signal transduction
GO_0010751Biological processnegative regulation of nitric oxide mediated signal transduction
GO_0045471Biological processresponse to ethanol
GO_0090277Biological processpositive regulation of peptide hormone secretion
GO_0090281Biological processnegative regulation of calcium ion import
GO_0070062Cellular componentextracellular exosome
GO_0004866Molecular functionendopeptidase inhibitor activity
GO_0004867Molecular functionserine-type endopeptidase inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPINK1
Protein nameSerine protease inhibitor Kazal-type 1 (Pancreatic secretory trypsin inhibitor) (Tumor-associated trypsin inhibitor) (TATI)
Serine peptidase inhibitor Kazal type 1
Pancreatic secretory trypsin inhibitor
SynonymsPSTI
DescriptionFUNCTION: Serine protease inhibitor which exhibits anti-trypsin activity . In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity). .; FUNCTION: In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production. .

AccessionsENST00000510027.2
D6RIU5
A2T2X6
P00995
A2T2X7
ENST00000296695.10