SPINDOC report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SPINDOC at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPINDOC at tissue level.

III. Associated gene sets

GO_0010835Biological processregulation of protein ADP-ribosylation
GO_0006974Biological processDNA damage response
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0090734Cellular componentsite of DNA damage
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPINDOC
Protein nameSpindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC)
Spindlin interactor and repressor of chromatin binding
SynonymsC11orf84
DescriptionFUNCTION: Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability . Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway . Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 . Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity . .

AccessionsENST00000540893.1
Q9BUA3
ENST00000535820.1
H0YGK9
H0YGY5
ENST00000294244.9