SPDYA | OmnibusX

Name	Number of supported studies	Average coverage
GABAergic neuron	3 studies	31% ± 22%	Explore
glutamatergic neuron	3 studies	42% ± 23%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPDYA at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	99%	44.52	1432 / 1445	53%	0.92	97 / 183
uterus	100%	71.35	170 / 170	27%	0.54	123 / 459
ovary	100%	95.47	180 / 180	24%	0.36	103 / 430
lung	100%	52.23	577 / 578	16%	0.38	188 / 1155
prostate	100%	55.64	245 / 245	8%	0.27	41 / 502
bladder	100%	35.33	21 / 21	7%	0.28	35 / 504
brain	97%	38.30	2571 / 2642	8%	0.13	59 / 705
breast	98%	48.15	452 / 459	5%	0.16	53 / 1118
stomach	97%	29.00	347 / 359	6%	0.16	18 / 286
kidney	96%	34.80	85 / 89	6%	0.12	57 / 901
thymus	100%	51.68	653 / 653	2%	0.02	11 / 605
intestine	98%	33.74	948 / 966	3%	0.09	17 / 527
skin	98%	43.65	1777 / 1809	2%	0.02	9 / 472
spleen	100%	53.58	241 / 241	0%	0	0 / 0
blood vessel	99%	77.58	1323 / 1335	0%	0	0 / 0
adipose	99%	41.77	1192 / 1204	0%	0	0 / 0
adrenal gland	98%	34.82	252 / 258	0%	0	0 / 230
pancreas	89%	20.40	291 / 328	3%	0.06	5 / 178
liver	90%	20.30	204 / 226	1%	0.01	4 / 406
heart	84%	27.38	727 / 861	0%	0	0 / 0
peripheral blood	82%	26.31	761 / 929	0%	0	0 / 0
muscle	64%	12.81	511 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	24%	0.35	11 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0070197	Biological process	meiotic attachment of telomere to nuclear envelope
GO_0007283	Biological process	spermatogenesis
GO_0006974	Biological process	DNA damage response
GO_0045737	Biological process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0045860	Biological process	positive regulation of protein kinase activity
GO_0016233	Biological process	telomere capping
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0070200	Biological process	establishment of protein localization to telomere
GO_0048477	Biological process	oogenesis
GO_0007140	Biological process	male meiotic nuclear division
GO_0000082	Biological process	G1/S transition of mitotic cell cycle
GO_0005654	Cellular component	nucleoplasm
GO_0005635	Cellular component	nuclear envelope
GO_0000781	Cellular component	chromosome, telomeric region
GO_0001741	Cellular component	XY body
GO_0005634	Cellular component	nucleus
GO_0019901	Molecular function	protein kinase binding
GO_0030295	Molecular function	protein kinase activator activity
GO_0005515	Molecular function	protein binding

Gene name	SPDYA
Protein name	Speedy/RINGO cell cycle regulator family member A Speedy protein A (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1)
Synonyms	SPDY1 SPY1
Description	FUNCTION: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 . Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation . Mediates cell survival during the DNA damage process through activation of CDK2 . .
Accessions	ENST00000449210.1 E7EPV1 Q5MJ70 ENST00000334056.10 [Q5MJ70-2] ENST00000439646.1 ENST00000379579.8 [Q5MJ70-2] H7C0J1

SPDYA report