SPATA18 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPATA18 at tissue level.

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0035695Biological processmitophagy by internal vacuole formation
GO_0035694Biological processmitochondrial protein catabolic process
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPATA18
Protein nameMitochondria-eating protein (Spermatogenesis-associated protein 18)
Spermatogenesis associated 18
SynonymsMIEAP
DescriptionFUNCTION: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. .

AccessionsENST00000505320.5
ENST00000295213.9 [Q8TC71-1]
ENST00000419395.6 [Q8TC71-2]
E7EVV3
D6RGI2
Q8TC71
ENST00000508915.5